Vaginal lubrication often occurs naturally during sexual excitement and arousal. Women vary in how much lubrication they produce and the amount of lubrication desired for pleasurable sexual activity — this variation is totally normal. Lubricants can be purchased online or at drugstores, many supermarkets, and sex-toy shops. Photo: Sydney Daoust cc. Comfort refers to your pleasure; the amount and staying power of the lubricant can make a difference in how good the sexual activity feels, and whether the lubricant irritates your genitals. Safety refers to your health; oil-based lubricants cannot be used with latex condoms, as they can destroy the latex and cause condom failure.